Growth hormone suppression test

定义

The growth hormone suppression test determines whether growth hormone (GH) production is being suppressed by high blood sugar.

选择的名字

GH suppression test; Glucose loading test; Acromegaly - blood test; Gigantism - blood test

如何执行测试

至少三个 血液样本 被.

The test is done in the following way:

• The first blood sample is collected between 6 a.m. 和8a.m. before you eat or drink anything.
• You then drink a solution containing glucose (sugar). You may be told to drink slowly to avoid becoming nauseated. But you must drink the solution within 5 minutes to ensure the test result is accurate.
• The next 血液样本 are usually collected for 1 to 2 hours after you finish drinking the glucose solution. Sometimes they 被 every 30 or 60 minutes.
• Each sample is sent to the laboratory right away. The lab measures the glucose and GH levels in each sample.

How to Prepare for the Test

DO NOT eat anything and limit physical activity for 10 to 12 hours before the test.

You may also be told to stop taking medicines that can affect the test results. These medicines include glucocorticoids such as prednisone, hydrocortisone, or dexamethasone. Check with your health care provider before stopping any medicines.

You will be asked to relax for at least 90 minutes before the test. This is because exercise or increased activity can change GH levels.

If your child is to have this test done, it may be helpful to explain how the test will feel and even demonstrate on a doll. The more familiar your child is with what will happen and why, the less anxiety the child will feel.

考试的感觉如何

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or slight bruising. 这很快就会消失.

Why the Test is Performed

This test checks for a high level of GH, a condition that leads to 巨人症 在儿童和 肢端肥大症 在成年人中. It is not used as a routine screening test. This test is only done if you show signs of increased GH.

正常的结果

Normal test results show a GH level of less than 1 ng/mL. In children, GH level may be increased due to reactive 低血糖症.

Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.

What Abnormal Results Mean

If the GH level is not changed and stays high during the suppression test, the provider will suspect 巨人症 or 肢端肥大症. You may need to be retested to confirm the test results.

风险

There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.

风险 of having blood drawn are slight, but may include:

• 大出血
• Multiple punctures to locate veins
• Fainting or feeling lightheaded
• Blood accumulating under the skin (血肿)
• Infection (a slight risk any time the skin is broken)

参考文献

凯泽，何凯. Pituitary physiology and diagnostic evaluation. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14日艾德. Philadelphia, PA: Elsevier; 2020:chap 8.

Nakamoto J. 内分泌检测. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7日艾德. Philadelphia, PA: Elsevier Saunders; 2016:chap 154.